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What is Cannabidiol (CBD oil)


You may ask “what is Cannabidiol oil”? Cannabidiol oil is also known as CBD Oil. CBD oil has been a hot topic over the last few years and is receiving more attention within the media after studies have published research highlighting the positive effects of CBD oil on health. The uses of CBD oil have also been highlighted by the growing number of celebrities and athletes using the oil in aiding their health and recovery from extreme schedules. Recently UFC fighter Nate Diaz in his press conference after the UFC 202 Connor McGregor fight discussed using CBD oil in a vaporising method to aid his recovery.

CDB oil can be ingested using different methods; vaporising, consuming it in its oil form or incorporating it with food. To gain optimum benefits from the CBD, you should ingest the oil by either consuming it as it is or incorporating it with your food.

Cannabinoid is a blanket term covering a family of complex chemicals; there are more than 80+ active cannabinoid chemicals in a marijuana plant. The most notable cannabinoid is the phytocannabinoids tetrahydrocannabinol(THC), the primary psychoactive compound found in marijuana cannabis. A more traditional method of gaining benefits from cannabinoids is to smoke marijuana cannabis. Contrary to popular belief therapeutic levels cannot be reached through smoking alone as the molecules of the cannabis plant are altered when the plant is heated. Cannabidiol (CBD) is another major phytocannabinoid found in the marijuana cannabis plant and is linked to the health benefits. Each of the isolated phytocannabinoid found in cannabis exhibit varied effects.

Scientists have found the Endo-cannabinoids system located in the brain and throughout the central and peripheral nervous systems consisting of neuromodulatory lipidsand theirreceptors. The endo-cannabinoid system has a vast array of functions in our bodies, including helping to control brain and nerve activity (memory and pain), energy metabolism, heart function, the immune system, and even reproduction.

Cannabinoids work by interacting with endo-cannabinoids system CB1 and CB2 receptors found in cells in the brain and body. CB1 Receptors are found on neurons and glial cells in various parts of the brain and nervous system. CB2 Receptors are found in the bodies immune system.

Cannabidiol (CBD) does not produce euphoria or intoxication effect unlike the main psychoactive cannabinoid chemical tetrahydrocannabinol (THC). The euphoric effects of THC are caused by its activation of CB1 receptors, whereas when CBD binds to these CB1 receptors it produces little to no effect because CBD has a very low affinity to the CB1 receptors. CBD acts as an antagonist at both CB1 and CB2 receptors. There is a growing body of research suggesting that CBD acts on other brain signalling systems, and this is an important contribution to its therapeutic effects and health benefits.

There is also a third family of cannabinoid receptors known as GPR, and the most notable receptor is GPR55. Less is known about these GPR receptors, however researchers are investigating them to see if they can lead to effective treatment of cancer.

 

References:

A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists, Vincenzo Di Marzo, Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, TRENDS in Pharmacological Sciences. 01.10.2006, Review, Science Direct.

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